Diversity of medicinal plants used for skincare by Bulungan tribe in North Kalimantan, Indonesia and its melanin biosynthesis inhibition
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Abstract. Kartina, Batubara I, Kuspradini H, Kusuma IW, Wahyuni WT, Egra S, Matsunaga T. 2022. Diversity of medicinal plants used for skincare by Bulungan tribe in North Kalimantan, Indonesia and its melanin biosynthesis inhibition. Biodiversitas 23: 1246-1253. Indigenous people of the Bulungan tribe in North Kalimantan, Indonesia have been utilizing plants for health purposes, including for skincare such as preventing skin from being dark due to melanin production. This study aimed to evaluate the diversity of medicinal plants utilized by the Bulungan tribe for skincare and determine the melanin biosynthesis inhibition activity. Plants having medicinal uses were investigated through literature studies and interviews with the members of Bulungan tribe in Tanjung Palas Tengah Village. Melanin biosynthesis inhibition was determined by identifying the tyrosinase inhibition potential using commercial tyrosinase enzyme, while intracellular and extracellular melanin biosynthesis production activity was determined using B16 melanoma cells. The results showed at least 19 plant species that have medicinal uses, including for skincare, with some of them having the potential for melanogenesis, both in suppressing and producing melanin. We found a plant sample with melanin suppression potential on B16 melanoma cell, namely Jatropha curcas, at 6.2 µg/ml concentration, which could decrease extracellular melanin content by 18%. Tyrosinase activity with L-tyrosine showed that Cinnamomum burmannii (root) (IC50: 3.4 ?g/mL) showed an insignificant difference with kojic acid, which served as positive control by showing an inhibitory level of (IC50: 0.14 ?g/mL). Based on the data obtained, a pharmacological study is recommended to investigate melanin biosynthesis as a skin whitening agent. We believe that this study can become basic data to discover several active compounds in future studies.
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References
Ang HH, Ngai TH, Tan TH. 2003. Effects of Eurycoma longifolia Jack on sexual qualities in middle aged male rats. Phytomedicine 10:590–593.
Arbain M. 2018. Buku Pintar Kebudayaan Tidung: Revitalisasi Kebudayaan Tidung yang Hampir Punah. Pustaka Ilmu, Yogyakarta.
Arung ET, Kuspradini H, Kusuma IW, Shimizu K, Kondo R. 2012. Validation of Euphatorium triplinerve vahl leaves, a skin care Herb fro North Kalimantan, using a melanin biosynthesis assay. J Acupunt Meridian Stud 5(2):87-92.
Arung ET, Pasedan WF, Kusuma IW, Hendra M, Supriadi MB. 2017. Selected medicinal plants in East and North Kalimantan (Indonesia) against Propionibacterium acnes. Biodiversitas Journal of Biological Diversity, 18(1): 4623-4630
Andrade-Cetto A, Heinrich M. 2005. Mexican plants with hypoglycaemic effect used in the treatment of diabetes. J. Ethnopharmacol 99: 325-348.
Cabanes J, Chazarra S, Garcia-Carmona F. 1994. Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase. J Pharm Pharmacol 46:982-985.
Carla WS, Ahmat N, Mohammad FJ, Sahidin I. 2013. Medicinal property, phytochemistry and pharmacology of several Jatropha species (Euphorbiaceae): A review. Phytochemistry 85:7–29.
Chan YY, Kim KH, Cheah SH. 2011. Inhibitory effects of Sargassum polycystum on tyrosinase activity and melanin formation in B16F10 murine melanoma cells. J ethnopharmacology 137:1183-1188.
Choi S, Lee, SK, Kim JE, Chung MH, Park YI. 2002. Aloesin inhibits hyperpigmentation induced by UV radiation. Clin.Exp. Dermatol 27:513-515.
Chikmawati T, Miftahudin. 2008. Biodiversitas dan potensi marga Selaginella sebagai antioksidan dan anti kanker. LPPM IPB, Bogor.
Chikmawati T, Setyawan AD, Miftahudin. 2008. Kandungan fitokimia ekstrak tumbuhan Selaginella di pulau Jawa. Seminar dan Kongres PTTI ke-VIII. Cibinong Science Center, Bogor-Indonesia, 21-23 October.
Chhabra SC, Mahunnah RLA, Mshiu EN. 1990. Plants used in traditional medicine in Northern Tanzania. III Angiosperms (Euophorbiaceae to Menispermaceae). J. Ethnopharmacol 28: 255.
Diana R, Matius P. 2017. Inventarisasi Tumbuhan Berkhasiat Obat yang Dimanfaatkan Masyarakat Suku Dayak Lundayeh. ULIN: Jurnal Hutan Tropis, 1(1):49-58
Dias DA, Urban S, Roessner U. 2012. A historical overview of natural products in drug discovery. Metabolites 2:303-336.
Hearing VJ. 2005. Biogenesis of pigment granules: a sensitive way to regulate melanocyte fuction. J Dermatol Sci. 37:3-14.
Hodek P, Trefil P, Stiborova M. 2000. Flavanoids – potent and versatile biologically active compounds interacting with cytochrome P450. Chemico-Biol. Int. 139 (1): 1-21.
Hufford CD, Oguntimein BO. 1978. Non-polar constituents of Jatropha curcas. Lloydia, 41: 161-165.
Ines FSV, Daniel FLM, Sofia M. 2012. Mechanism regulating melanogenesis. A Bras Dermatol. 88(1):76-83.
Jones K, Hughes J, Hong M, Jia Q, Orndorff S. 2002. Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase. Pigment Cell Res 15:335-340.
Kaneko JJ, Harvey JW, Bruss ML. 1997. Clinical Biochemistry of Domestic Animals. Academic Press, San Diego, USA, pp. 932.
Kassim MJ, Hussin HH, Achmad A, Dahon NH, Suan TK, Hamdan HS. 2011. Determination of total phenol, condensed tannin and flavonoid contents and antioxidant activity of Uncaria gambir extracts. Indonesia Journal of Pharmacy 22:50–59.
KEMENKES RI. 2015. Laporan Riset Khusus Eksplorasi Pengetahuan Lokal Etnomedisin dan Tumbuhan Obat Berbasis Komunitas di Indonesia. Balitbangkes Kemenkes RI. 55 pp.
Khafagy SM, Mohamed YA, Abdel SNA, Mahmoud ZF. 1977. Phytochemical study of Jatropha curcas. Planta Med., 31: 274-277.
Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, et al. 2003. Cytotoxic and antimalaria ?-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod 66:1324-7.
Listiani L, Abrori FM. 2019. Ethnobotanical Study on Tidung Tribe in Using Plants for Medicine, Spice, and Ceremony, IPTEK. The Journal for Technology and Science 29(1):18-24.
Thomson, Lex AJ, and Randolph R. Thaman. 2006. "Pometia pinnata (tava)." Spesies Profiles for Pacific Island Agroforestry. 2.1(4):1-16
Mariam A, Chung PL, Gabriel AA, Nur NI, Mohammad AH, Sook YH, Lee FA, Mun FY. 2013. Safety assessment of standardised methanol extract of Cinnamomum burmannii. Phytomedicine 20:1124–1130.
Mitsunaga T, Yamauchi K. 2015. Effect quercetin derivative on melanogenesis stimulation of melanoma cells. J Wood Sci 61:351-363.
Neuwinger HD. 1994. African Arzneip ances and hunting poisons. WV Gesmb H, Germany, p. 450.
Nobori T, Miura K, Wu DJ, Takabayashi LA, Carson DA. 1994. Deletion of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 368 (6473): 753-756.
Nora MO, Thommas PO, Yvonne O, David AF. 2010. Cytotoxic and Apoptotic effects of Stigmasterol Oxides in U937 Cells. Department of Chemistry, Analytical and Biological Chemistry Research, University College Cork, Ireland.
Parvez S, Kang M, Chung HS, Cho C Hong MC Shin MK, Bae H. 2006. Survey and mechanism of skin depigmenting and lightening agents. Phytotherapy research 20:921-934.
Pattalung PN, Wiriyachitra P, Ongsakul M. 1988. The antimicrobial activities of rubraxanthone isolated from Garcinia parvifolia MIQ. J. Sci. Soc Thailand 14:67-71.
Payyappallimana U, Fadeeva Z. 2012. Innovation in Local and Global Learning Systems for Sustainability: Traditional Knowledge and Biodiversity – Learning Contributions of the Regional Centres of Expertise on Education for Sustainable Development UNU-IAS, Yokohama, Japan.
Puri RK. 2001. The Bulungan Ethnobiology Handbook: A Field Manual for Biological and Social Science Research on the Knowledge and Use of Plants and Animals Among 18 Indigenous Groups in Northern East Kalimantan, Indonesia. CIFOR.
Udhayasankar MR, Dany U, Punitha ID, Arumugasamy K. 2013. In vitrocytotoxic activity of methanolic extract of Cardiospermum canescens Wall. (Sapindaceae). Research in Pharmacy 3(3):01-05.
Rukachaisirikul V, Naklue W, Phongpaichit S, Hutadilok TN, Manenoon K. 2006. Phloroglucinols, depsidones and xanthones from the twigs of Garcinia parvifolia. Tetrahedron 62:8578-8585.
Sanchez-FA, Rodrigez-LJN, Garcia-CF. 1995. Tyrosinase: a comprehensive review of its mechanism. Biochim Biophys Acta 1247:1-11.
Shimizu K, Kondo R, Sakai K. 2001. Novel vitamin E derivative with 4-substituted resorcinol moiety has both antioxidant and tyrosinase inhibitory properties, Lipids 36:1321–1326.
Solano F, Briganti S, Picardo M, Ghanem G. 2006. Hypopigmenting agents: an update riviewon biological and clinica aspects. Pigment cell research. 19:550-571.
Srivastava, Jitendra, Lambert, Vietmeyer V. 1996. Medicinal plant: An expanding role in development. World Bank Technical Paper. No.320
Staubmann R, Neuble I, Gubitz GM, Steiner W, Read JS. 1999. Esterase and lipase activity in Jantropha curcas L. seeds. J. Biothechnol 75: 117-126.
Staubmann R, Manfred S, Alois H, Theodor K. 1999. A complex of 5-hydroxypyrrolidin-2-one and pyrimidine-2,4-dione isolated from Jatropha curcas. Phytochemistry 50: 337-338.
Sturm RA, Teasdale RD, Box NF. 2001. Human pigmentation genes: identification, structure and consequences of polymorphic variation. Gene 277:49-62.
Suedee A, Tewtrakul S, Panichayupakaranant P. 2013. Anti-HIV-1 integrase compound from Pometia pinnata leaves. Pharm boil 51(10):1256-1261.
Susanti R, Zuhud EA. 2019. Traditional ecological knowledge and biodiversity conservation: the medicinal plants of the Dayak Krayan people in Kayan Mentarang National Park, Indonesia. Biodiversitas Journal of Biological Diversity, 20(9) : 2764-2779
Tsamali M, Ancans J, Thody AJ. 2002. Melanocyte fuction and its control by melanocortin peptides. The journal of histochemistry and cytochemistry 50:125-133.
Wang KH, Lin RD, Hsu FL, Huang YH, Chang HC, Huang CY, Lee MH. 2006. Cosmetic applications of selected traditional Chinese herbal medicine. J Ethnopharmacol 106:353-359.
Woehrlin F, Fry H, Abraham K, Preiss-Weigert. 2010. Quantification of flavoring constituents in cinnamon: high variation of coumarin in Cassia Bark from the German retail market and in authentic samples from Indonesia. Journal of Agricultural and Food Chemistry 58:10568–10575.
Xu YJ, Chiang PY, Lai YH, Vittal JJ, Wu XH, Tan BKH, Imiyabir Z, Goh SH. 2000. Cytotoxic Prenylated Depsidones from Garcinia parvifolia. Journal of natural products.
Xu YJ, Lai YH, Imiyabir Z, Goh SH. 2001. Xanthones from Garcinia parvifolia. J. Nat. Prod 64:1191-1195.
Yamauchi K, Mitsunaga T, Itakura Y, Batubara I. 2015. Extracellular melanogenesis inhibitory activity and the structure-activity relationships of ugonins from Heliminthostachys zelanica roots. Fitoterapia 104:69-74.
Yoshida M, Takahashin T, Inoue S. 2000. Histamine induces melanogenesis and morphologic changes by protein kinase A activation via H2 receptors in human normal melanocyte. J Invest Dermatol 114:334-342.
Zhang J, Liu L, He Y, Kong W, Huang S. 2010. Cytotoxic effect of trans-cinnamaldhyde on human leukemia K 562 cells. Acta Pharmacologica Sinica 31:861–866.
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